Journal of the Korean Medical Association, 2015, 02, 1044─1059

미세먼지/황사 건강피해 예방 및 권고지침: 심혈관질환 Guidelines for the prevention and management of cardiovascular disease associated with fine dust/Asian dust exposure

김인수, 김창수, 정보영 Ji-Yong Jang, Tae-Hoon Kim, Junbeom Park, Jaemin Shim, Jin-Bae Kim, Young Sup Byun, Jung-Hoon Sung, Young Won Yoon, Jong-Youn Kim, Yang-Je Cho, Changsoo Kim, Boyoung Joung, 장지용, 김태훈, 박준범, 심재민, 김진배, 변영섭, 성정훈, 윤영원, 김종윤, 조양제

Abstract

Epidemiological studies have demonstrated an increased risk for cardiovascular events in relation to both short- and long-term exposure to ambient particulate matter (PM). Several plausible mechanistic pathways have been described, including an enhanced propensity for arrhythmias, systemic inflammatory responses, and the chronic promotion of atherosclerosis. On the basis of this review, several new findings were reached, including the following: exposure to PM including PM <2.5 μm in diameter can trigger cardiovascular disease-related mortality; longer-term exposure (e.g., a few years) increases the risk for cardiovascular mortality; reductions in PM levels are associated with decreases in cardiovascular mortality within a period as short as a few years; and many credible pathological mechanisms have been elucidated that lend biological plausibility to these findings. It is the opinion of the writing group that the overall evidence is consistent with a causal relationship between PM exposure and cardiovascular morbidity and mortality. Finally, PM exposure is deemed a modifiable factor that contributes to cardiovascular morbidity and mortality. The purpose of this statement is to develop evidence-based practical guidelines for healthcare professionals and regulatory agencies with a comprehensive review of the literature on air pollution and cardiovascular disease and a specific focus on the clinical implications.

• ISBN or ISSN: 1975-8456

• 본 연구는 질병관리본부 연구개발과제(과제번호 2014-ER2703-00) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2014-ER2703-00) by Research of Korea Centers for Disease Control and Prevention.