Obesity Research and Clinical Practice, 2015, 01, 336─345

Prediction of future risk of insulin resistance and metabolic syndrome based on Korean boy’s metabolite profiing

AeJin Lee, Han Byul Jang, Moonjin Ra, Youngshim Choi, Hye-Ja Lee, Ju Yeon Park, Jae Heon Kang, Kyung-Hee Park, Sang Ick Park, Jihyun Song

Abstract

Objective
Childhood obesity is strongly related to future insulin resistance and metabolic syndrome. Thus, identifying early biomarkers of obesity-related diseases based on metabolic pro-ling is useful to control future metabolic disorders. We compared metabolic proles between obese and normal-weight children and inves- tigated speci？c biomarkers of future insulin resistance and metabolic syndrome.
Methods
In all, 186 plasma metabolites were analysed at baseline and after 2 years in 109 Korean boys (age 10.5 ± 0.4 years) from the Korean Child Obesity Cohort Study using the AbsoluteIDQTM p180 Kit.
Results
We observed that levels of 41 metabolites at baseline and 40 metabolites at follow-up were signi？cantly altered in obese children (p < 0.05). Obese children showed signi？cantly higher levels of branched-chain amino acids (BCAAs) and sev- eral acylcarnitines and lower levels of acyl―alkyl phosphatidylcholines. Also, baseline BCAAs were signi？cantly positively correlated with both homeostasis model assess- ment for insulin resistance (HOMA-IR) and continuous metabolic risk score at the 2-year follow-up. In logistic regression analyses with adjustments for degree of obe- sity at baseline, baseline BCAA concentration, greater than the median value, was identi？ed as a predictor of future risk of insulin resistance and metabolic syndrome.
Conclusion
High BCAA concentration could be ‘‘early’’ biomarkers for predicting future metabolic diseases.

• ISBN or ISSN: 1871-403X

• 본 연구는 질병관리본부 연구개발과제(과제번호 2012-NG64001-00) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2012-NG64001-00) by Research of Korea Centers for Disease Control and Prevention.