2013년 한국분자세포생물학회(KSMCB 2013), 2013, 02, 120─120

Ethanol consumption induces the alteration of fetus development during pregnancy: Through serotonin dysregulation in pancreatic b-cells

EunAe Jeong, Dae-yeon Lee, Ji Yeon Kim, Keon Jae Park, Gyu Hee Kim, Won-Ho Kim

Abstract

Pregnancy drinking is considered as a major risk factor for the metabolic disorders in pregnancy women and detrimental fetal growth, and thus induces the fetal programming with several chronic diseases including obesity and diabetes. However, the effects of ethanol consumption and the exact regulatory mechanism associated with the development of impaired glucose tolerance of pregnant mother and the abnormal development of fetus. Here, we found that the rates of pregnancy and fertility were decreased in ethanol-fed mice compared to those of pair-fed mice, correlated with the delaying of eye formation during embryo development in ethanol-fed mice. Birth weight in pair-fed mice was lower than that of ethanol-fed mice in postnatal 0-day (P0). Our data also show that these abnormal fetus development may be caused by the maternal pancreatic β-cell dysfunction through alter-regulation of serotonin-mediated insulin synthesis and secretion. Taken together, our results suggest that ethanol consumption before pregnancy is a major causing factor for the detrimental fetus development and maternal metabolic disorders, especially on the dysregulation of serotonin on pancreatic β-cells

• 본 연구는 질병관리본부 연구개발과제(과제번호 2012-NG63002-00) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2012-NG63002-00) by Research of Korea Centers for Disease Control and Prevention.