2013 International conference on Diabetes and Metabolism(2013 ICDM), 2013, 02, 166─166

Relationship of DGLA-related desaturase activities to insulin resistance in Korean boys

Youngshim Choi, Han Byul Jang, Hyo Jung Lee, Ju Yeon Park, HyeJa Lee, JaeHeon Kang, KyungHee Park, Jong Ho Lee, Jihyun Song

Abstract

Obesity in youth increases the risks for obesity and metabolic disorders in adulthood. Since the fatty acid composition in tissues or blood is reported to be closely associated with obesity, and metabolic disorders, tracking the plasma phospholipid fatty acid composition with metabolic parameters in youth could strengthen the usefulness of fatty acid composition as an early biomarker for future metabolic disorders. To investigate the longitudinal associations of plasma fatty acid composition with body fatness and insulin resistance in Korean children, the anthropometric data, and blood biochemistry data of 131 Korean boys aged 10.5 ± 0.5 years were obtained both at baseline and 2 years later. Their fatty acid composition (%) of plasma phospholipid was analyzed and the desaturase activity was estimated: delta-6 desaurase (D6D, 20:3n-6/18:2n-6) and delta-5 desaurase (D5D, 20:4n-6/20:3n-6). Obese boys showed significantly higher percentage of palmitoleic acid (16:1n-7) at baseline and dihomo-gamma linolenic acid (DGLA, 20:3n-6) at baseline and follow-up than non-obese children. SCD16 and D6D were higher in obese boys than non-obese boys at baseline. DGLA and D6D were positively associated with adiposity indices and homeostasis model of assessment-insulin resistance (HOMA-IR), a surrogate marker of insulin resistance. The baseline D6D showed also close relationship with follow-up insulin resistance index and TG content. Thus early detection of higher D6D activity in Korean boys could predict the future insulin resistance and associated metabolic disorders such as dyslipidemia.

• 본 연구는 질병관리본부 연구개발과제(과제번호 2012-NG64001-00) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2012-NG64001-00) by Research of Korea Centers for Disease Control and Prevention.