Journal of Medical Genetics, 2014, 01, 782─788

Intake levels of dietary polyunsaturated fatty acids modify the association between the genetic variation in PCSK5 and HDL cholesterol

Han Byul Jang, Joo-Yeon Hwang, Ji Eun Park, Ji Hee Oh, Youn Jhin Ahn, Jae-Heon Kang, Kyung-Hee Park, Bok-Ghee Han, Bong Jo Kim, Sang Ick Park, Hye-Ja Lee

Abstract

Background
A low serum level of high-density lipoprotein cholesterol (HDL-C) is a risk factor for cardiovascular disease. Proprotein convertase subtilisin/ kexin type 5 (PCSK5) modulates HDL-C metabolism through the inactivation of endothelial lipase activity.
Methods
Therefore, we analysed the effects of PCSK5 on HDL-C and investigated the association between genetic variation in PCSK5 and dietary polyunsaturated fatty acids (PUFAs) intakes in Korean adults and children.
This population-based study which was conducted in South Korea included 4205 adults (43% male) aged 40？69 years and 1548 children (48.6% boys) aged 8？ 13 years. Dietary intake was assessed using a semiquantitative food frequency questionnaire in adults and modi？ed 3-day food records in children.
Results
After adjustments for age and body mass index, we identi？ed a signi？cant association between SNP rs1029035 of the PCSK5 gene and HDL-C concentrations speci？cally for men in both populations (adults, p=0.004; children, p=0.003; meta, p=7×10？4 ). Additionally, the interaction between the PCSK5 rs1029035 genotype and dietary polyunsaturated fatty acids intake in？uenced serum HDL-C concentrations in men (adults, p=0.001; children, p=0.008). The deleterious effect of the C allele on serum HDL-C was present only when dietary PUFA intake was less than the dichotomised median level (adults, p=0.011; children, p=0.001). Serum HDL-C concentrations were decreased in men with the C allele genotype and low consumption of dietary PUFA including n-3 and n-6.
Conclusion
According to these results, men carrying of the C allele were associated with low HDL-C concentrations and might exert bene？cial effects on HDL-C concentrations following consumption of a high-PUFA diet.

• ISBN or ISSN: 0022-2593

• 본 연구는 질병관리본부 연구개발과제(과제번호 2013-NG64001-00) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2013-NG64001-00) by Research of Korea Centers for Disease Control and Prevention.