Nutrition, Metabolism ; Cardiovascular Diseases, 2014, 01, 83─90

Interactions between ADIPOQ gene variants and dietary monounsaturated: saturated fatty acid ratio on serum lipid levels in Korean children

J.Y. Park, J.Y. Park, H.-J. Lee, H.B. Jang, J.-Y. Hwang, J.H. Kang, B.-G. Han, J.-Y. Lee, J. Song

Abstract

Background and aims
Adiponectin plays important roles in the regulation of insulin action and metabolism of glucose and lipids. We investigated whether ADIPOQ genetic variants are associated with serum lipid levels in Korean children and whether those in？uences might be modulated by dietary factors such as dietary monounsaturated fatty acid to saturated fatty acid ratio (MUFA:SFA).
Method and results
The study included a population-based sample of 687 children aged 7e11 years in Gwacheon city, Kyunggi Province, Korea. Anthropometric and biochemical measure- ments and ADIPOQ genotype ( 11377 C/G, þ45 T/G, and þ276 G/T) were determined. Dietary intake was estimated with a self reported 3-day food diary. The 11377 G allele carriers had signi？cantly higher serum total cholesterol and LDL cholesterol compared to non-carriers. When dietary MUFA:SFA ratio was dichotomized (MUFA:SFA 1or <1), the aggravating effects of the minor allele on serum total and LDL cholesterol were only present when the MUFA:SFA ratio was <1. Additionally, we observed that the ADIPOQ haplotype in？uenced serum total and LDL cholesterol levels. GeTeG haplotype carriers had higher total and LDL cholesterol levels than non-GeTeG carriers. The deleterious effect of ADIPOQ GeTeG haplotype to increase serum total and LDL cholesterol could be seen only when the MUFA:SFA ratio was <1.
Conclusion
In this present study, we found interaction effects between ADIPOQ genetic vari- ants and dietary MUFA:SFA ratio on serum lipid levels in Korean children. These results suggest that individual genetic information and dietary fatty acid intake information should be as- sessed together to achieve an effective outcome for reducing the atherogenic lipid pro？le.

• ISBN or ISSN: 0939-4753

• 본 연구는 질병관리본부 연구개발과제(과제번호 2012-NG64001-00) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2012-NG64001-00) by Research of Korea Centers for Disease Control and Prevention.