Human Molecular Genetics, 2014, 01, 5492─5504

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index

Wen W, Zheng W, Okada Y, Takeuchi F, Tabara Y, Hwang JY,

Abstract

Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations.
We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488？47 352 additional Asian-ancestry individuals.
We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29E - 013), ALDH2/MYL2 (rs671, P = 3.40E -011; rs12229654, P = 4.56E - 029), ITIH4 (rs2535633, P = 1.77E - 010) and NT5C2 (rs11191580, P = 3.83E - 08) genes.
The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 3 1028) and an additional 14 at P < 1.0 3 1023 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity

• ISBN or ISSN: 0964-6906

• 본 연구는 질병관리본부 연구개발과제(과제번호 2012-N73002-00) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2012-N73002-00) by Research of Korea Centers for Disease Control and Prevention.