Genomics, 2014, 01, 594─598

A genome-wide association study identifies a LEPR gene as a novel predisposing factor for childhood fasting plasma glucose

Go MJ, Kim BJ

Abstract

To date, genome-wide population-based association studies have been predominantly conducted on genetic predispositions in adult individuals.
In uncovering childhood FPG susceptibility, a combined meta-analysis identified a novel LEPR locus (rs17407594) reaching genome-wide significance (n = 1,260, Padd = 4.98E - 08).
We also observed an association with T2D risk in the AGEN consortium (n = 18,817, Padd = 2.06E - 02).
In conclusion, our findings might expand understanding of genetic architecture contributing to glucose regulation and T2D risk

• ISBN or ISSN: 0888-7543

• 본 연구는 질병관리본부 연구개발과제(과제번호 2012-N73002-00) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2012-N73002-00) by Research of Korea Centers for Disease Control and Prevention.