Human Vaccines & Immunotherapeutics, 2014, 01, 1181─1186

Obesity-induced Chronic Inflammation is Associated with the Reduced Efficacy of Influenza Vaccine

hye-Lim Park, S Shim, E Lee, S Park, H Jeon, S Ahn, H Kim, J Nam

Abstract

The relationship between obesity and vaccine efficacy is a serious issue. Previous studies have shown that vaccine efficacy is lower in the obese than in the non-obese. Here, we examined the influence of obesity on the efficacy of influenza vaccination using high fat diet (HFD) and regular fat diet (RFD) mice that were immunized with 2 types of influenza virus vaccines―cell culture-based vaccines and egg-based vaccines. HFD mice showed lower levels of neutralizing antibody titers as compared with RFD mice. Moreover, HFD mice showed high levels of MCP-1 in serum and adipocytes, and low level of influenza virus-specific effector memory CD8+ T cells. After challenge with influenza virus, the lungs of HFD mice showed more severe inflammatory responses as compared with the lungs of RFD mice, even after vaccination. Taken together, our data suggested that the inflammatory condition in obesity may contribute to the suppressed efficacy of influenza vaccination.

• ISBN or ISSN: 2164-5515

• 본 연구는 질병관리본부 연구개발과제(과제번호 2009-인수공통(용)-4) 연구비를 지원받아 수행되었습니다.
• This research was supported by a fund(code 2009-zoonotic disease-4) by Research of Korea Centers for Disease Control and Prevention.