본문으로 바로가기 주메뉴 바로가기

사용자별 맞춤메뉴

자주찾는 메뉴

추가하기
닫기

연구성과

contents area

detail content area

Associations of Mitochondrial Deoxyribonucleic Acid Polymorphisms With Behçet's Disease in the ...
  • 작성일2020-08-07
  • 최종수정일2020-08-07
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 662

Archives of Rheumatology, 2019. 34(2), 211-219, DOI: https://doi.org/10.5606/ArchRheumatol.2019.7113


Associations of Mitochondrial Deoxyribonucleic Acid Polymorphisms With Behçet's Disease in the Korean Population

Mihye KWON, Su-jin YOO;In Seol YOO;Jinhyun KIM;Seong Wook KANG;In Ah CHOI;Mi-kyoung LIM;Chung-il JOUNG


Abstract

    Objectives: This study aims to examine the possible associations of mitochondrial single nucleotide polymorphisms (SNPs) and Behçet’s disease(BD) in a larger patient group.

    Patients and methods: Whole blood or buffy coat was collected from 98 BD patients (31 males, 67 females; mean age 48±2.8 years;range 20 to 60 years) from four university hospitals located in the Chung-Cheong district of the Republic of Korea, and 196 age- and sex-matchedhealthy controls (HCs) (62 males, 134 females; mean age 46.91±12.90 years; range 20 to 68 years) from Konyang University Hospital. Twenty targetedmitochondrial deoxyribonucleic acids (DNAs) were genotyped and compared using the revised Cambridge Reference Sequence. Chi square andFisher’s exact tests were used to analyze association of mitochondrial DNA SNPs with BD susceptibility and its clinical characteristics.

    Results: There were no differences for m.248A>G, m.304C>A, m.709G>A, m.3010G>A, m.3970C>T, m.4883C>T, m.5178C>A, m.6392T>C,m.6962G>A, m.10310G>A, m.10609T>C, m.12406G>A, m.12882C>T, m.13928G>C, m.14668C>T, m.16129G>A, and m16304T> between patient and HCgroups. However, m.16182A>C and m.16183A>C were more frequently observed in the patient group than the HC group (22 [22.4%] vs. 24 [12.2%],p=0.061 and 32 [32.7%] vs. 42 [21.4%], p=0.092) but without statistical significance. m.4883C>T and m.5178C>A were associated with posteriorlocation of oral ulcers (p=0.025 for each) and m.16183A>C was associated with deep oral ulcers (p=0.001), while m.16189T>C was associated withdeep oral ulcers and thrombosis (p=0.042, 0.048, respectively).

    Conclusion: m.16182A>C and m.16183A>C may be associated with BD in the Korean population.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


본 공공저작물은 공공누리  출처표시 조건에 따라 이용할 수 있습니다 본 공공저작물은 공공누리 "출처표시" 조건에 따라 이용할 수 있습니다.
TOP