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Length at birth z-score is inversely associated with an increased risk of bronchopulmonary dysplasia
  • 작성일2020-05-07
  • 최종수정일2020-05-07
  • 담당부서연구기획과
  • 연락처043-719-8033
  • 291

PLOS ONE, 2019. 14(5), e0217739-, DOI: https://doi.org/10.1371/journal.pone.0217739


Length at birth z-score is inversely associated with an increased risk of bronchopulmonary dysplasia or death in preterm infants born before 32 gestational weeks: A nationwide cohort study

Young Hwa Jung, Youngmi Park; Beyong Il Kim; Chang Won Choi


Abstract

    ObjectiveWe investigated whether the extent of fetal growth restriction (FGR) in terms of not only birthweight but length and head circumference at birth is correlated with an increased risk of bronchopulmonary dysplasia (BPD) in preterm infants.

    Study design A total of 4,940 very low birth weight (VLBW) infants born between 23 and 31 weeks of gestationfrom 2013 to 2015 who were registered in the Korean Neonatal Network (KNN) databasewere enrolled. Infants with major congenital malformations and those with incompletedata were excluded. Z-scores for weight, length, and head circumference at birth were calculatedfrom the Fenton 2013 growth curve. Multivariable logistic regression analysis wasperformed to determine whether the z-score for length at birth was associated with BPD ordeath before 36 postmenstrual weeks.

    Results A total of 4,662 VLBW infants were analyzed: 518 infants died before 36 postmenstrualweeks; 1,388 infants developed BPD. Decreased length at birth z-scores were significantlyassociated with an increased risk of BPD or death when adjusted for covariates (odds ratio(OR) 1.25 per 1-point decrease of length at birth z-score, 95% confidence interval (CI) 1.14–1.37). The association was particularly evident in infants born earlier than 29 weeks of gestation(OR 1.57, 95% CI 1.31–1.89 in infants born at 23–25 weeks; OR 1.24, 95% CI 1.09–1.42 in infants born at 26–28 weeks).

    Conclusion Length at birth was inversely associated with an increased risk of BPD or death in VLBWinfants born earlier than 32 weeks of gestation.



  • 본 연구는 질병관리본부 연구개발과제연구비를 지원받아 수행되었습니다.
  • This research was supported by a fund by Research of Korea Centers for Disease Control and Prevention.


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