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KNIH/ Division
of Structural and Functional Genomics |
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| The Division
of Structural and Functional Genomics
performs the "Korean Genome Analysis
Project (KoGAP)", whose main focus
is on the identification of disease-associated
genes using SNP (single nucleotide polymorphism),
the most common genetic variation in
the human genome. As the largest genomics
research group of the country, we have
established an |
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| integrated pipeline system for
genome research which operates as follows:
selection of candidate genes or genomic regions,
LD block partitioning, haplotype construction,
disease association studies, and function
analyses of genetic variants. We also started
genome-wide association studies using high-throughput
genotyping technologies, especially newly
developed high density SNP chips (100K &
500K). |
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| The analysis of multiple loci
located on separate chromosomes using the
high-powered technologies for genome-wide
studies is expected to provide an excellent
strategic track for searching disease genes,
which are causally associated with human complex
diseases. |
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| The genomic approaches to human
complex diseases should facilitate the identification
of disease genes and will finally provide
invaluable strategies and methodologies for
the prevention, accurate diagnosis and improved
treatment of such complex diseases as diabetes,
hypertension, asthma, and osteoporosis, through
better understanding the molecular basis of
the complex traits disorders resulting from
the complex influences of multiple genes.
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194, Tongil-Lo, Eunpyung-Gu, Seoul, 122-701,
Korea TEL : 82-2-357-2605~10, FAX : 82-2-357-0532
Copyright by KCDC. All Rights Reserved. |
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